PROF. GUANG ZHU
The Hong Kong University of Science and Technology, Hong Kong
Professor, Division of Life Science
Director, the Biological NMR Center, The Hong Kong University of Science and Technology (2016-).
My group is interested in (1) Structure-functional study of DNA, RNA and their complexes with protein in gene activation and gene silencing. (2) Development of multidimensional NMR spectroscopic methods for structure-function studies of biomolecules, (3) Structure-functional study of proteins in human DNA replication by NMR, x-ray crystallography and cryo-EM,
(4) Structural and functional study of DNA and RNA G-quadruplexes involved in human neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis and cancers. (5) Lead compound screening and design by NMR targeting these disease related G-quadruplexes.