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The Hong Kong University of Science and Technology, Hong Kong


Professor, Division of Life Science

Director, the Biological NMR Center, The Hong Kong University of Science and Technology (2016-).


My group is interested in (1) Structure-functional study of DNA, RNA and their complexes with protein in gene activation and gene silencing. (2) Development of multidimensional NMR spectroscopic methods for structure-function studies of biomolecules, (3) Structure-functional study of proteins in human DNA replication by NMR, x-ray crystallography and cryo-EM,

(4) Structural and functional study of DNA and RNA G-quadruplexes involved in human neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis and cancers. (5) Lead compound screening and design by NMR targeting these disease related G-quadruplexes.

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